Prime Video’s popular comedy-dramaHarlemincludes a talented ensemble of actors who give great performances. Premiering in 2021 with its last season airing in early 2025,Harlemfollows four friends, Camille, Quinn, Angie, and Tye, who are trying to find a balance in their personal and professional lives after graduating college. Like Issa Rae’s 2010sInsecure,Harlemfocuses on telling stories about Black women and how they navigate the day-to-day challenges.
Harlemonly has a handful of main characters,with renowned actors such as Whoopi Goldberg, Andrea Martin, and Jasmine Guy in the show’s supporting cast. Most of the actors inthe Prime Video original serieswill be familiar to audiences as they have starred in many popular movies and TV shows, includingAnchorman 2,Empire, andShazam!,to name a few.Harlem’s cast is obviously at the center of the show, and their clever performances elevate the series.

Meagan Good As Camille
Date Of Birth: June 06, 2025
Actor:Meagan Good was born in Los Angeles, California.Good got her big acting break when she took on the role of Cisely BatisteinEve’s Bayou. Nowadays, Good is best known for starring inThink Like aMan,The Unborn, andBrick. She’s also had roles inShazam!,Anchorman 2: The Legend Continues,Tyler Perry’s Divorce in the Black,Day Shift, andCalifornication.
Saw V
Luba
Character:Camille, one of the four leads ofHarlem, is an anthropology professor at Columbia University who is struggling in her career. Other than issues with her job, Camille has to navigate a complicated love life when her ex-boyfriend returns to Harlem.
Grace Byers As Quinn
Date Of Birth: June 23, 2025
Actor:Born in Butler, Pennsylvania,Grace Byers gained recognition for her role as Anika Calhoun on the hit TV show,Empire. She is best known for starring inThe Blackening,Phoenix, andBent. Byers has also had roles inThe Gifted, andThe Retirement Plan.
Bent
Kate
Character:Byers' Quinn is a fashion designer whose company isn’t making enough money, so she has to rely on her wealthy parents to fund her life. Quinn loves love, but it’s difficult for her to find someone she can have a serious relationship with.
Jerrie Johnson As Tye Reynolds
Date Of Birth: Jun 11, 2025
Actor:Jerrie Johnson was born in Philadelphia, Pennsylvania. She is a relatively new actor with only four acting credits to her name.Johnson is best known for starring inHarlem, which is her breakout role, in addition toMother’s Milk, Survival of the Thickest, andGood Trouble.
Mother’s Milk
Sweetbird
Character:Tye is a tech entrepreneur who has a bit of a messy love life. She doesn’t open up easily in her romantic relationships, but she is always there for her three best friends, even when they are not getting along.
Shoniqua Shandai As Angie
Date Of Birth: July 21, 2025
Actor:Born in New York,Shoniqua Shandai is best known for appearing inBodiedandSing It!. She’s also had roles inI Am the Night,Nobodies,Sierra Burgess Is a Loser, andSisters!.
Sing It!
Crystal
Character:Of the four best friends, Angie is the one who doesn’t seem to have a lot going on for her professionally. While she tries to make strides in her music career, things don’t always go her way.
Tyler Lepley As Ian
Date Of Birth: June 14, 2025
Actor:Tyler Lepley was born in Doylestown, Pennsylvania. After beginning his acting career,Lepley finally got his big break in Tyler Perry’s show,The Haves and the Have Nots. The actor has also starred inBaggage Claim,P-Valley, andBuried Alive and Survived.
The Haves and the Have Nots
Buried Alive and Survived
Victor
Character:Played by Tyler Lepley, Ian is a chef and Camille’s ex-boyfriend. After he returns to Harlem, he and Camille rekindle their romance, but their relationship faces new challenges.
Harlem Supporting Cast & Characters
Whoopi Goldberg as Dr. Elise Pruitt:Whoopi Goldberg is one of the most recognizable actors starring inHarlem. She has had roles in a variety of TV shows and movies, such asSister Act,The Color Purple,Instinct, andGlee. The actor and comedian is currently one of the hosts of the talk showThe View.
Jasmine Guy as Patricia:Born in Boston, Massachusetts, Jasmine Guy is best known for starring inGrey’s Anatomy,Harlem Nights,The Vampire Diaries, andA Different World.
Bevy Smith as Aunt Tammy:The author, talk show host, and actor Bevy Smith takes on the role of Aunt Tammy inHarlem. She is mostly recognized for her appearances inThe TableandRun the World.
Juani Feliz as Isabela Benitez-Santiago:Born in the Dominican Republic, Juani Feliz began her acting career in 2005. She has had roles in 2024’s acclaimedCivil War, as well asThe Good Doctor,Law & Order: Criminal Intent, andBlue Bloods.
Rachel True as Aimee:Since beginning her acting career in the 1990s with a small role inBeverly Hills, 90210, and a leading one in the cult classicThe Craft, Rachel True has starred in many movies and TV shows. She is mostly recognized for her roles inHalf & Half,The Craft,HalfBaked, andSharknado 2: The Second One.
Kate Rockwell as Anna Sharp:Kate Rockwell takes on the role of Anna Sharp inHarlem. Rockwell has had roles inTick, Tick… BOOM!,Almost Family, andBlue Bloods.
Jonathan Burke as Eric:Jonathan Burke has appeared in several movies and TV shows since getting his BFA in musical theater. He can be seen in noteworthy titles such as Hulu’sOnly Murders in the Building,New Amsterdam, andThe Distinguished.
Sullivan Jones as Jameson Royce: Sullivan Jones has had an impressive career in the film and TV industry. He is mostly recognized for his roles inThe Blacklist,The Gilded Age,Halston,Interior Chinatown, andAtlanta.
Trai Byers as Keith:Born on August 16, 2025, Trai Byers takes on the role of Keith inHarlem. He has also starred inEmpire,Selma,90210, andThe 24th.
Kadeem Harris as Brandon:Born in New York, Kadeem Harris is best known for his roles inHarlem,City on a Hill, andThe Farmhouse Massacre.
Andrea Martin as Robin Goodman:With over 175 credits to her name, Andrea Martin has had roles in some of the most beloved movies and TV shows. She is mostly recognized for starring as Aunt Voula inMy Big Fat Greek Wedding, as well as characters inEvil,Only Murders in the Building,Greta News, andThe Good Fight.
Erika Henningsen as Kate:Hazbin Hotel’s Erika Henningsen takes on the role of Kate inHarlem. The actor has also starred inBlue Bloods,Helluva Boss, andGirls5eva.